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KMID : 0360320000320050911
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Journal of Korean Cancer Research Association
2000 Volume.32 No. 5 p.911 ~ p.917
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Combination Chemotherapy with Cisplatin and Vinorelbine in Patients with Non-Small-Cell Lung Cancer
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김기원:Kim Kee-Won
박석영:Park Suk-Young/서지원:Suhr Ji-Won/김승준:Kim Seung-Joon/양동헌:Yang Dong-Hoen/이은희:Lee Eun-Hee/이경식:Lee Kyung-Shick
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Abstract
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Purpose: To determine the therapeutic effect and toxicities of cisplatin and vinorelbine combination chemotherapy in patients with inoperable non-small-cell lung cancer. Materials and Methods: Between Jan 1998 and Dec 1999, 28 patients with inoperable non- small-cell lung cancer were treated with cisplatin and vinorelbine combination chemotherapy as induction treatment. A combination of vinorelbine 25 mg/m2 day 1,8 and cisplatin 60 mg/m2 day 1 were giv0n and repeated every 3 weeks. Then we assessed response and toxicity according to WHO grades. Results: According to response criteria, there were 1 complete response, 12 partial response (42.9%), 12 stable disease (42.9%), and 3 progression (10.7%). The median survival was 12 months. According to toxicity grades, 24 grade 3 myelosuppression (24.7%), 12 grade 4 myelosuppression (10.7%), 6 grade 3 and 4 constipation (6.1%), and mild 7 (7.2%) thrombophlebitis were experienced in evaluable 97 cycles. There was no other clinically severe toxicity. Conclusion: These results suggest that combination chemotherapy with cisplatin and vinorelbine in patients with inoperable non-small-cell lung cancer was effective and safe.
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KEYWORD
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Non-small-cell lung cancer, Chemotherapy, Vinorelbine, Cisplatin,
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